Science
Mechanism of Action
Functions as a dual-action anti-aging peptide by downregulating inflammatory cytokines (IL-4, IL-6, TNF-alpha) while simultaneously upregulating key structural proteins including procollagen, elastin, decorin, fibronectin, and hyaluronic acid in the dermal matrix. Additionally reduces advanced glycation end products and strengthens barrier function.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 16-week study showed significant improvements in jawline sagging, nasolabial folds, fine lines, and hyperpigmentation
- 02 12-week clinical trial demonstrated reduction in pre-aging signs and decreased skin glycation index
Transparency
Dusting Analysis
As a premium peptide ingredient with documented clinical efficacy, unlikely to be dusted in quality formulations, though specific concentration data is proprietary
The Formula
Formulation
Stability
Enhanced stability due to amidation protecting against enzymatic degradation. Must be incorporated below 40°C during cooling phase to preserve peptide structure.
Conflicts
- Strong oxidizing agents
- Strongly acidic environments (pH < 4.0)
- Strongly alkaline environments
Safety
Safety Profile
Listed in EU CosIng database (ID 98053) as skin protecting agent. Clinical tolerability studies show no significant edema or erythema reactions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed multipeptide with demonstrated clinical efficacy for comprehensive anti-aging, though concentration transparency remains limited in commercial products.
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References
Sources