Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ACETYL METHIONINE.

Valuable CAS 1115-47-5 / 65-82-7 / SKIN CONDITIONING

An acetylated amino acid derivative that functions as both a hydrating humectant and protective antioxidant in skincare formulations. This water-soluble ingredient supports the skin's natural moisturizing factor while simultaneously defending against environmental oxidative stress. Its dual-action mechanism makes it particularly effective in anti-aging and hydrating treatments.

Summary

humectant antioxidant skin conditioning

Science

Mechanism of Action

Functions through two primary pathways: acts as a humectant by mimicking components of the skin's natural moisturizing factor to maintain hydration levels, and serves as an antioxidant by scavenging reactive oxygen species from UV and pollution exposure. Additionally supports endogenous glutathione synthesis within skin cells, enhancing the skin's internal defense mechanisms against oxidative damage.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 Demonstrated superior antioxidant efficacy compared to N-acetyl-L-tryptophan in protecting human serum albumin from oxidative damage
  2. 02 Clinical validation in amino acid complexes shows significant improvement in skin hydration and NMF support at 0.1-1.0% concentrations

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Given the established effective range of 0.1-1.0%, concentrations below 0.05% are unlikely to provide meaningful hydrating or antioxidant benefits

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

Maintains stability under standard cosmetic storage conditions but requires protection from temperatures above 85°C to prevent denaturation

Synergies

  • other amino acids
  • hyaluronic acid
  • glycerin
  • antioxidant complexes

Conflicts

  • strong oxidizing agents
  • strong acids
  • strong bases

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Pregnancy
Safe
Sensitization risk Low

CIR Expert Panel confirms safety for cosmetic use when formulated to be non-irritating. Also holds FDA GRAS status as a food additive.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A well-researched dual-function ingredient that delivers both hydration and antioxidant protection with excellent safety profile across all skin types.

Related

Similar Ingredients

Finding similar ingredients…