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ACETYL MANDELIC ACID.

Valuable CAS 51019-43-3 / 7322-88-5 / BUFFERING

A dual-action alpha-acetoxy acid that strengthens skin barrier integrity while delivering controlled mandelic acid exfoliation through hydrolysis. This versatile compound functions simultaneously as a gentle AHA precursor, antimicrobial preservative, and pH buffering agent in skincare formulations.

buffering skin conditioning antimicrobial exfoliation

Science

Works through a pH-dependent dual mechanism: remains stable in acidic conditions to reinforce corneocyte cohesion and thicken stratum corneum, while gradually hydrolyzing into mandelic acid to provide gentle exfoliation and antimicrobial benefits for acne-prone skin


Research

Medium confidence
Effective range 0.0125–2%
Optimal

2%

Key findings

  1. 01 2% concentration promotes corneocyte cohesion and keratin stabilization for nail hardening applications
  2. 02 0.0125% demonstrates effective antimicrobial action against S. aureus and P. aeruginosa with fungal colony reduction

Transparency

Not commonly dusted

Professional-grade ingredient with established efficacy at clinically relevant concentrations


The Formula

Solubility
Both
Optimal pH 3 – 4.5
0 7 14

Stability

Requires pH-controlled environments or anhydrous systems to prevent premature hydrolysis; highly soluble in water and organic solvents including methanol and acetone

Conflicts

  • Strong bases
  • Strong oxidizing agents
  • Metal ions

Safety

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

Used in professional dermatological formulations at 2% levels; classified as skin and eye irritant in concentrated raw form


Your Skin

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated multifunctional acid that delivers controlled exfoliation with barrier-strengthening properties for normal to oily skin types.


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