Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ACETYL HEXAPEPTIDE-8 OLIGOPEPTIDE-133.

Valuable / SKIN CONDITIONING

This synthetic peptide, primarily evaluated as Acetyl Hexapeptide-8 (Argireline), is noted for its ability to reduce expression lines by influencing facial muscle contractions. It also actively supports skin health by stimulating collagen production and enhancing hyaluronic acid levels, contributing to improved firmness, elasticity, and hydration.

Summary

Humectant Skin conditioning Anti-aging Wrinkle reduction Firming Elasticity improvement Hydration

Science

Mechanism of Action

Acetyl Hexapeptide-8, widely known as Argireline, operates as a biomimetic peptide that specifically targets the cellular machinery responsible for muscle contraction. By disrupting the formation and stability of the SNARE complex, it effectively modulates the release of neurotransmitters, leading to a visible reduction in the intensity of facial muscle contractions and, consequently, dynamic wrinkles. Furthermore, this ingredient contributes to skin's structural integrity and hydration by encouraging endogenous collagen synthesis and elevating hyaluronic acid concentrations.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–0.2%
Optimal

0.2%

Key findings

  1. 01 A 0.2% active concentration demonstrated significant improvements in both wrinkle depth and number following four weeks of twice-daily application.
  2. 02 Formulations containing a 10% solution of Acetyl Hexapeptide-8 showed a 17% decrease in wrinkle depth around the eyes after 15 days.
  3. 03 A 5% formula concentration resulted in a 16.26% reduction in wrinkle depth after 28 days.
  4. 04 A 10% concentrated solution reduced deep wrinkles by 27% after 30 days of twice-daily application.
  5. 05 Concentrations of 3% and 5% were found safe and effective for scalp care, providing anti-aging benefits and improving scalp elasticity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Acetyl Hexapeptide-8 exhibits optimal stability within a pH range of 4.0 to 7.0, though formulation pH is also suggested between 3.5 and 6.5. Its hydrophilic nature and relatively large molecular size necessitate strategic formulation approaches, such as oil-in-water (O/W) or multiple water-in-oil-in-water (W/O/W) emulsions, to enhance skin penetration and deposition. Mixing temperatures must be maintained below 40 °C, as higher temperatures or excessive dosages may reduce efficacy.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.005%
Sensitization risk Low

All available safety and efficacy data pertains specifically to Acetyl Hexapeptide-8 (Argireline) and its variants; information for the exact combined ingredient 'ACETYL HEXAPEPTIDE-8 OLIGOPEPTIDE-133' was not found. The CIR Expert Panel concluded Acetyl Hexapeptide-8 Amide is safe in cosmetics at concentrations up to 0.005%, but indicated insufficient data for evaluating safety at higher concentrations. This ingredient is not listed as restricted or prohibited by the EU and is not recognized as a drug by the FDA.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Acetyl Hexapeptide-8, the key component of this ingredient, offers valuable 'botox-like' anti-aging benefits by moderating muscle contractions and boosting collagen and hyaluronic acid, though specific research for the complete ACETYL HEXAPEPTIDE-8 OLIGOPEPTIDE-133 combination is currently unavailable.

Related

Similar Ingredients

Finding similar ingredients…