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Moumoujus

ACETYL HEXAPEPTIDE-51 AMIDE.

Valuable / SKIN CONDITIONING

Acetyl Hexapeptide-51 Amide is a sophisticated synthetic peptide engineered to enhance the skin's inherent DNA repair mechanisms and bolster cellular resilience. It actively mitigates genetic damage induced by UV radiation and environmental stressors, while concurrently combating cellular senescence to preserve youthful skin function and appearance.

Summary

DNA Repair Enhancement Photoprotection Anti-aging Cellular Senescence Reversal Skin Conditioning Antioxidant

Science

Mechanism of Action

This synthetic peptide operates as a biomimetic of FOXO3a, a crucial transcription factor involved in DNA damage response, cellular renewal, and longevity pathways. By activating natural DNA repair processes, it helps maintain genomic stability by minimizing replication errors and safeguarding skin cells from various stressors, including UV exposure and pollutants. Its comprehensive action supports overall skin integrity, delays the visible signs of aging by reversing cellular senescence, and also contributes to skin conditioning.

Research

Clinical Evidence

Medium confidence
Effective range 3–10%
Optimal

N/A

Key findings

  1. 01 In manufacturer studies, application led to a 13.7% decrease in UV radiation-induced genetic damage within the nuclei of human epidermal cells after 6 hours.
  2. 02 Human dermal fibroblasts exposed to simulated sunlight demonstrated a 35.1% increase in cell viability compared to untreated irradiated cells, showcasing a significant photoprotective effect.
  3. 03 Manufacturer/supplier data indicates a 16.6% reduction in UV-mediated DNA damage and a reversal of cellular senescence within 24 hours.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

The peptide maintains optimal stability within a pH range of 4.0 to 7.0. In its dry powder form, it remains stable at room temperature for a minimum of 12 months. Once reconstituted in aqueous or hydroalcoholic solutions, it should be utilized within 4-6 weeks or stored frozen in aliquots to prolong usability, as it is susceptible to moisture and degradation if not handled correctly.

Conflicts

  • Strong acids and alkalines can lead to pH-related stability issues. While it can be formulated alongside ingredients such as Vitamin C or retinoids, careful consideration of pH or staggering product application is recommended to minimize potential conflicts and maximize ingredient efficacy.

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
10%
Sensitization risk Low

Direct comprehensive safety assessments by bodies such as CIR, SCCS, or FDA specifically for Acetyl Hexapeptide-51 Amide are not extensively available in the provided data. It is generally recognized as safe for topical use at concentrations up to 10%. It is important to distinguish this ingredient from Acetyl Hexapeptide-8 Amide, which has separate CIR reports. Side effects are relatively uncommon, though individual patch testing is recommended. Inhalation of the powder form should be avoided.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Hexapeptide-51 Amide is a valuable ingredient for its precise DNA repair, photoprotective, and anti-aging capabilities, effectively shielding skin from damage and promoting cellular longevity.

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