Science
Mechanism of Action
Acetyl Hexapeptide-37 exerts its primary action by upregulating the expression of Aquaporin-3 (AQP3), integral water channels found within skin cell membranes. This facilitates the efficient movement of water from the deeper epidermal layers towards the stratum corneum, thereby boosting overall skin hydration. Additionally, it promotes the proliferation of keratinocytes, which fortifies the skin's natural barrier function and effectively minimizes transepidermal water loss. The peptide also stimulates dermal fibroblasts to increase Collagen Type I synthesis, a crucial process for maintaining skin's structural integrity, enhancing firmness and elasticity, and ultimately diminishing the appearance of fine lines and wrinkles.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 131% improved skin hydration was observed in 20 female volunteers (aged 30-50) after 56 days of twice-daily application of a product containing Acetyl Hexapeptide-37 at a concentration of 10 µg/ml (Lipotec S.A. in-vivo study).
- 02 An in-vitro study demonstrated increased Aquaporin-3 (AQP3) mRNA expression in human keratinocytes when treated with Acetyl Hexapeptide-37 at concentrations of 50 ng/ml and 250 ng/ml (Lipotec S.A. in-vitro study).
Transparency
Dusting Analysis
Current research data does not provide typical inclusion percentages in cosmetic products to establish a dusting threshold. Experimental concentrations indicate high efficacy at low levels.
The Formula
Formulation
Stability
While specific optimal pH ranges are not explicitly stated, peptides generally require consideration of pH for optimal stability in formulations. Its comparatively low molecular mass may benefit from the inclusion of penetration enhancers to facilitate deeper skin absorption.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Panel has not yet conducted a specific review for Acetyl Hexapeptide-37. While CIR reports regarding a similar peptide, Acetyl Hexapeptide-8, concluded its safety up to 0.005%, this assessment does not directly apply to Acetyl Hexapeptide-37. However, Acetyl Hexapeptide-37 is widely recognized by cosmetic ingredient databases and suppliers as a safe ingredient, with SkinSAFE categorizing it as 'Irritant Free'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl Hexapeptide-37 is a valuable ingredient, offering significant benefits in boosting skin hydration and supporting anti-aging processes through its precise mechanisms in enhancing water channel activity, fortifying the skin barrier, and stimulating collagen synthesis.
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