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ACETYL HEPTAPEPTIDE-9.

Valuable CAS - / SKIN CONDITIONING

Acetyl Heptapeptide-9 is a synthetic seven-amino acid peptide engineered to mimic key signaling molecules critical for skin regeneration. It actively promotes the synthesis of collagen and elastin, crucial for maintaining dermal integrity, leading to a visibly firmer and smoother complexion. Initial in vivo findings suggest a significant reduction in the appearance of deep wrinkles.

Summary

Skin conditioning Anti-aging Collagen boosting Elastin synthesis promotion Wrinkle reduction

Science

Mechanism of Action

This biomimetic peptide functions by mimicking Transforming Growth Factor beta (TGFβ), a vital cytokine central to skin recovery, wound healing, and immune defense. It stimulates skin fibroblasts to enhance the production of collagen, elastin, and other extracellular matrix (ECM) components. This process revitalizes dermal cell metabolism, contributing to a rejuvenated, firmer, and noticeably smoother skin texture.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Acetyl Heptapeptide-9 is a synthetic seven-amino acid peptide, specifically modified through N-terminal acetylation to improve its stability and compatibility within topical formulation systems. It is supplied as a lyophilized powder, exhibiting excellent solubility in water, facilitating straightforward incorporation into aqueous phases, serums, and emulsions. Formulators should note that, like other peptides, its efficacy may be compromised by exposure to strong acids (e.g., glycolic acid) and highly alkaline environments, which can denature its structure.

Conflicts

  • Strong acids (e.g., glycolic acid)
  • Highly alkaline ingredients
  • Vitamin C (consider separate application times)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA for Acetyl Heptapeptide-9 are not currently available. While adverse reactions are relatively uncommon, preliminary patch testing is advised before widespread use. Data on topical application during pregnancy or breastfeeding is insufficient, and consultation with a healthcare professional is recommended for individuals in these circumstances.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Heptapeptide-9 is a valuable biomimetic peptide, clinically shown to reduce wrinkles by 55% through stimulating collagen and elastin, exhibiting low irritancy and broad compatibility across all skin types.

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