Science
Mechanism of Action
Acetyl Glutamine functions as a multifaceted skin optimizer. As a humectant and skin-conditioning agent, it actively draws and retains moisture, significantly improving the skin's barrier integrity. It promotes cellular renewal and regeneration, bolstering the skin's intrinsic defenses. Furthermore, this glutamine derivative provides essential precursors for structural proteins like collagen and elastin, regulates cellular hydration by influencing aquaporin-3 (AQP-3) expression, and stimulates the synthesis of glycosaminoglycans (GAGs), including hyaluronic acid, for comprehensive hydration and skin plumpness. Its action extends to improving skin cell metabolism and contributing to a more balanced skin tone and a non-aggressive reduction in fine lines and wrinkles.
Research
Clinical Evidence
Medium confidence1%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Acetyl Glutamine exhibits superior stability compared to free glutamine, particularly in aqueous solutions and under conditions such as sterilization or low pH. It remains stable for a minimum of 6 months at pH values exceeding 4.0, at approximately 20°C. Degradation products, including N-(2,6-dioxo-3-piperidinyl) acetamide and pyroglutamic acid, may emerge below pH 4.0 (e.g., pH 2.0-3.0). Stability was confirmed in a liquid nutritional product at pH 6.5 over 3 months.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel, in their 2017 report, evaluated Acetyl Glutamine in 8 products containing up to 1% concentration and concluded it is safe for use. It is noted for its low concern regarding use restrictions and potential for irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable amino acid derivative that significantly enhances skin hydration and barrier function while offering anti-aging benefits through cellular support and structural protein precursors.
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