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Moumoujus

ACETYL GLUCOSAMINE.

Valuable CAS 10036-64-3 / SKIN CONDITIONING

Acetyl Glucosamine is a sophisticated amino sugar that significantly enhances skin hydration by boosting the natural production of hyaluronic acid. This multi-functional ingredient also precisely targets hyperpigmentation through melanin inhibition and promotes gentle surface exfoliation, revealing a smoother, more radiant complexion.

Summary

Supports natural hydration and elasticity Reduces hyperpigmentation and brightens skin tone Promotes gentle cellular turnover and exfoliation Provides antioxidant protection against free radicals Minimizes the appearance of fine lines and wrinkles Soothes skin and strengthens barrier function

Science

Mechanism of Action

As a skin-identical ingredient, Acetyl Glucosamine actively improves dermal health through several precise mechanisms. It serves as a crucial precursor for the biosynthesis of hyaluronic acid, thereby directly augmenting skin moisture content and elasticity. Furthermore, it potently inhibits tyrosinase, the enzyme central to melanin formation, which effectively reduces the appearance of hyperpigmentation and evens skin tone. Its mild keratolytic properties facilitate the gentle detachment of dead skin cells, promoting cellular turnover without the harshness associated with stronger exfoliants. Additionally, Acetyl Glucosamine acts as an antioxidant, neutralizing damaging free radicals, and possesses anti-inflammatory benefits that support skin barrier function and aid in wound healing.

Research

Clinical Evidence

High confidence
Effective range 1–5%
Optimal

2%

Key findings

  1. 01 Demonstrated significant improvement in skin moisture levels, a noticeable reduction in pigment spots, and provided gentle exfoliation.
  2. 02 Showed marked improvement in the appearance of wrinkles, particularly in the delicate eye area, and visibly faded brown spots in double-blind clinical trials.
  3. 03 Proven effective in reducing visible discolorations, with enhanced performance observed when combined synergistically with niacinamide for comprehensive skin tone evening.
  4. 04 Significantly contributed to the reduction of hyperpigmentation, indicating a powerful combination effect.
  5. 05 Consistently recognized for its efficacy and excellent skin tolerability across various formulations.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 7.5
0 7 14

Stability

Acetyl Glucosamine is a highly water-soluble crystalline powder (167 mg/mL), facilitating its seamless incorporation into aqueous-based formulations such as serums, creams, and gels. Optimal stability and efficacy are maintained within a precise pH range of 6.0 to 7.5.

Synergies

  • Niacinamide (Vitamin B3) for enhanced reduction of hyperpigmentation and improved overall skin tone, with notable efficacy at a 4% Acetyl Glucosamine and 2% Niacinamide combination.

Conflicts

  • strong acids
  • strong bases
  • oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has rigorously assessed Acetyl Glucosamine, concluding its safety for use in cosmetics under current practices and concentrations, provided formulations are non-irritating. It is safely utilized in leave-on facial and neck products at concentrations up to 5%. In vitro assays consistently demonstrate its non-irritating and non-sensitizing profile, confirming its suitability for sensitive skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Glucosamine is a highly valuable, multi-active ingredient that offers clinically supported benefits for superior hydration, targeted brightening, gentle exfoliation, and anti-aging, demonstrating excellent compatibility across all skin types with a low risk of irritation or comedogenicity.

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