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Moumoujus

ACETYL DIPEPTIDE-31 AMIDE.

Valuable / SKIN CONDITIONING

Acetyl Dipeptide-31 Amide is a cutting-edge micropeptide engineered to precisely combat the visible signs of aging by targeting both inflammatory processes and the degradation of the skin's structural components. It works to enhance skin resilience, improve firmness, and boost hydration through sophisticated cellular support mechanisms.

Summary

Skin conditioning Anti-inflammatory Collagen synthesis booster Elastin synthesis booster Hyaluronic acid synthesis booster Firming Elasticity enhancing Hydration boosting Anti-aging Skin barrier support

Science

Mechanism of Action

This micropeptide precisely targets 'inflammaging' by significantly downregulating key inflammatory cytokines including IL-4, IL-6, IL-8, IL-17, and TNF-α. Concurrently, it actively promotes the synthesis of vital extracellular matrix (ECM) components such as pro-collagen, hyaluronic acid, elastin, decorin, and fibronectin. With a compact molecular weight of 229 Daltons and an optimized structure, it ensures efficient epidermal penetration, influencing cellular pathways that enhance barrier function, skin plumping, and overall epidermal metabolism.

Research

Clinical Evidence

High confidence
Effective range 0.01–0.4%
Optimal

0.4%

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding the dusting potential of Acetyl Dipeptide-31 Amide is available within the provided research.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The acetylation of Dipeptide-31 confers enhanced stability and optimized efficacy upon skin application. Its specific molecular structure ensures ready penetration into the skin, irrespective of the formulation vehicle, be it a cream, lotion, or water-in-silicone base.

Synergies

  • Demonstrates compatibility within complex formulations, having been effectively combined with ingredients like glycolic acid, acetyl tyrosinamide, gluconolactone, and bakuchiol in clinical studies, suggesting broad synergistic potential.

Conflicts

  • As a general consideration for dipeptides, there is a potential for degradation by proteases produced by certain bacteria, such as E. coli. This may necessitate careful attention to product preservation and stability strategies.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Preclinical investigations did not indicate concentration-related cytotoxicity. Clinical studies reported excellent tolerability, with no statistically significant increases from baseline in adverse reactions like edema, erythema, dryness, burning, stinging, itching, or tightness. While side effects are generally uncommon, patch testing is recommended for individual assessment. Data specifically concerning topical use during pregnancy or breastfeeding are currently unavailable, therefore, consultation with a healthcare professional is advised. There is no specific review by the CIR, SCCS, or FDA status for this ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Dipeptide-31 Amide is a highly valuable ingredient for advanced skincare, offering multifaceted benefits by precisely targeting inflammatory aging and significantly enhancing skin's structural integrity, as supported by robust clinical data.

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