Science
Mechanism of Action
This tripeptide, also known as Bodyfensine®, functions by stimulating keratinocytes to produce human beta-defensins (hBD-2 and hBD-3), which are key antimicrobial peptides. By enhancing these natural defenses, it helps to rebalance the skin's microbiome, guarding against acne and infections, and supporting the skin's natural healing and recovery processes.
Research
Clinical Evidence
Medium confidence0.05%
Transparency
Dusting Analysis
While the maximum suggested concentration for cosmetic formulations is 0.05%, this level is considered efficacious for its targeted action. The clinical study, although using a '5% solution' (implying a lower active ingredient concentration), supports its potential benefits, suggesting that usage at appropriate levels is purposeful rather than merely for label claims.
The Formula
Formulation
Stability
Optimal stability is observed within a pH range of 5.0 to 7.0, making it compatible with various emulsion types. For optimal peptide integrity, it should be incorporated into formulations during the final manufacturing stage, ensuring processing temperatures do not exceed approximately 40 °C. The powder form requires cool, dark, dry storage at 2-8°C, shielded from light, or at -20°C for extended periods.
Safety
Safety Profile
No explicit CIR or SCCS assessment is available. It is listed with an FDA UNII (4RW8NHT736). Supplier data indicates no heavy metals and no significant skin or eye irritation when used at recommended concentrations. While some sources caution that peptides are for research purposes, Acetyl Dipeptide-3 Aminohexanoate is widely used and reported as a cosmetic ingredient, with a maximum recommended concentration of 0.05% in cosmetic formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl Dipeptide-3 Aminohexanoate is a valuable ingredient for precision skincare, particularly for enhancing the natural defenses of oily, sensitive, and acne-prone skin by promoting a balanced microbiome.
Related
Similar Ingredients
Finding similar ingredients…