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ACETYL DECAPEPTIDE-3.

Valuable CAS - / SKIN CONDITIONING

Acetyl Decapeptide-3 is a biomimetic synthetic peptide engineered to mimic the effects of basic fibroblast growth factor (bFGF). It is designed to enhance the dermal matrix by stimulating the production of structural proteins and improving skin hydration.

Summary

Anti-aging Skin firmness enhancement Skin elasticity improvement Wrinkle reduction Fine line reduction Skin regeneration Collagen synthesis stimulation Elastin synthesis stimulation Hyaluronic acid synthesis enhancement Skin hydration Cell proliferation promotion Wound healing support

Science

Mechanism of Action

This synthetic peptide, also identified as CG-Rejuline, operates by mimicking the biological activity of basic fibroblast growth factor (bFGF) within the skin. It actively promotes the synthesis and healthy development of Type I, Type II, and Type IV collagen, alongside elastin, leading to a measurable increase in skin thickness and enhanced elasticity. Acetyl Decapeptide-3 stimulates the proliferation of fibroblasts, endothelial cells, and keratinocytes, which are crucial for skin regeneration. Furthermore, it significantly enhances hyaluronic acid synthesis, contributing to improved skin moisture content and a visible reduction in fine lines. By increasing the expression of vital extracellular matrix proteins such as collagen, fibronectin, and laminin, it works to achieve firmer, suppler skin with improved overall texture and reduced wrinkles. It also offers cellular protection against apoptosis and has applications in promoting hair growth and strengthening follicles.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information regarding 'dusting' or typical ingredient concentrations for consumer products was provided in the research data.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

Acetyl Decapeptide-3 remains stable at normal temperatures when shielded from light. To ensure its integrity, formulations should avoid high temperatures, elevated humidity, and repeated cycles of freezing and thawing. For short-term storage (up to 6 months), it should be kept sealed and light-proof between 2-8°C. For extended storage (up to 24 months), vacuum-packing at -20°C to -80°C is recommended.

Conflicts

  • strong oxidants (e.g., peroxyacids, which can release toxic gases)
  • strong acids
  • strong bases

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Acetyl Decapeptide-3 has demonstrated a low potential for irritation to both skin and eyes. Typical analyses indicate an absence of heavy metals.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Acetyl Decapeptide-3 is a valuable biomimetic peptide with robust mechanistic evidence for enhancing skin structure, elasticity, and hydration, positioning it as a promising ingredient for comprehensive skin rejuvenation.

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