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Moumoujus

ACETYL CARNOSINE.

Valuable CAS 56353-15-2 / SKIN PROTECTING

Acetyl Carnosine is a highly stable dipeptide derivative prized for its multi-faceted protective actions against skin aging. It effectively combats oxidative stress and glycation, fundamental processes that compromise skin integrity and youthful appearance. This ingredient is designed to bolster skin's natural defenses, promoting firmness, elasticity, and an even tone.

Summary

Antioxidant Anti-aging Anti-glycation Skin Conditioning Wound Healing Support Improves Firmness Enhances Elasticity Evens Skin Tone

Science

Mechanism of Action

Acetyl Carnosine functions as a potent antioxidant, meticulously neutralizing reactive oxygen species (ROS) and free radicals to safeguard cells and tissues from oxidative damage and inflammation. Furthermore, it acts as a strategic anti-glycation agent, intercepting the formation of Advanced Glycation End-products (AGEs) by serving as a 'sugar trap.' This dual action is vital for preserving the structural integrity and flexibility of collagen and elastin, directly enhancing skin firmness and elasticity. Its design as a prodrug ensures superior stability against enzymatic degradation, allowing for sustained delivery of carnosine to target skin tissues.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–2%
Optimal

0.5%

Key findings

  1. 01 A 0.5% aqueous solution of Acetyl Carnosine demonstrated a 7.3% reduction in UVB-induced erythema in human skin, indicating its photo-protective capabilities.
  2. 02 While primarily ophthalmic, clinical applications at 1% and 2% have shown benefits such as slowing lens opacity progression and improving visual acuity in early-stage senile cataracts, suggesting potent anti-aging and protective properties relevant to tissue health.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 5.5
0 7 14

Stability

This prodrug exhibits significantly enhanced stability within liquid formulations and biological systems compared to L-Carnosine. Pharmaceutical-grade preparations achieve a 24-month shelf life under appropriate storage conditions. However, direct aqueous solutions prepared from crystalline solid are not recommended for extended storage beyond one day and require dilution, filtration, and sterilization before use.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

Acetyl Carnosine is generally regarded as safe and well-tolerated in cosmetic applications, presenting a low risk of toxicity or irritation even with prolonged use. Its ophthalmic use, primarily as a dietary supplement, lacks comprehensive safety and efficacy data from drug trials.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Carnosine is a valuable ingredient, offering robust antioxidant and anti-glycation benefits essential for maintaining skin's youthful integrity and protecting against environmental stressors.

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