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ACETAMIDOETHOXYETHANOL.

Valuable CAS 118974-46-2 / HUMECTANT

Acetamidoethoxyethanol is a high-performance, multi-functional humectant engineered to deliver both immediate and prolonged skin hydration. It actively strengthens the skin's natural barrier and provides soothing benefits across all skin types.

humectant moisturizer skin-conditioning soothing barrier-strengthening pH-stabilizer active-delivery-enhancer

Science

This ingredient functions as a potent humectant, leveraging its low molecular weight to deeply penetrate the skin. It binds water molecules to keratin, bio-mimicking the skin's Natural Moisturizing Factors (NMF) to sustain hydration for up to 30 hours. By stabilizing skin pH and reinforcing barrier lipids, it minimizes transepidermal water loss (TEWL) and enhances overall barrier integrity. Furthermore, its unique acetamido group contributes to reducing inflammation and redness, while its flexibility improves the uniform delivery of other active ingredients.


Research

High confidence
Effective range 1–10%
Optimal

5%


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Acetamidoethoxyethanol is primarily water-soluble yet possesses amphiphilic characteristics, enabling it to integrate seamlessly with both hydrophilic and lipophilic ingredients. This dual nature supports formulation stability and ensures consistent active delivery. It is noted for being non-sticky and easily spreadable, although improper stabilization or incompatibility with specific actives or preservatives may compromise product shelf life or texture.

Synergies

  • Enhances delivery and uniform distribution of other active ingredients
  • Stabilizes formulations by combining with both water and oil-soluble components

Conflicts

  • Incompatibility with specific actives or preservatives
  • Inadequate stabilization, potentially shortening shelf life or altering texture

Safety

CIR Status
Not reviewed
Sensitization risk Low

While generally regarded as safe with a favorable stability profile, formal safety assessments by CIR, SCCS, or FDA are not documented. It presents a low risk of irritation and offers soothing properties. However, individuals with exceptionally reactive skin might experience mild stinging or redness, particularly at elevated concentrations or when formulated poorly for sensitive areas like around the eyes.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An advanced humectant that delivers multi-faceted hydration, barrier support, and soothing benefits across all skin types, positioning it as a valuable asset in sophisticated skincare formulations.


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