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ACETALDEHYDE ETHYL CIS-3-HEXENYL ACETAL.

Optional CAS 28069-74-1 / PERFUMING

A fragrance compound that delivers a fresh, green scent profile to skincare formulations while potentially offering cooling sensations through TRPM8 receptor modulation. This acetal-based ingredient demonstrates excellent stability in alkaline environments and maintains low irritation potential across all skin types.

perfuming

Science

Functions primarily as a perfuming agent providing green olfactory notes, with emerging research suggesting it may modulate TRPM8 receptors to create cooling sensations on skin and mucous membranes.


Research

High confidence
Effective range 0.02–2%
Optimal

0.02%

Key findings

  1. 01 Safe for skin contact and inhalation at 95th percentile fragrance concentration levels
  2. 02 Maximum safe usage level confirmed through human repeat insult patch testing without sensitization

Transparency

Not commonly dusted

Used specifically as a fragrance component rather than active ingredient, making dusting concerns irrelevant for this application.


The Formula

Solubility
Oil
Optimal pH 7 – 10
0 7 14

Stability

Demonstrates high stability in alkaline conditions but undergoes hydrolysis in acidic environments, breaking down into constituent aldehyde and alcohol components.

Conflicts

  • Acidic formulations (pH < 6.0)
  • Strong oxidizing agents

Safety

CIR Status
Not reviewed by CIR
Max tested
2%
Sensitization risk Low

IFRA-compliant with extensive RIFM safety assessment. FDA-approved as flavoring agent. Dermal LD50 exceeds 5 g/kg in animal studies.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient suitable for all skin types when sensory enhancement is desired in formulations.


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