Science
Mechanism of Action
Functions through high concentrations of salidroside and quercetin to inhibit Thymic Stromal Lymphopoietin (TSLP) and IgE production, suppressing inflammatory cytokines IL-4, IL-5, and IL-13. Simultaneously provides antioxidant protection via DPPH and ABTS+ radical scavenging, protecting against H2O2-induced oxidative stress.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 One-week topical application significantly reduced atopic dermatitis lesions and ear swelling in NC/Nga mouse models through Th2 immune response inhibition
- 02 0.23% concentration achieved 50% free radical scavenging in DPPH assays, outperforming standard antioxidant controls
Transparency
Dusting Analysis
Efficacious concentrations start at 0.23% based on antioxidant studies, with therapeutic benefits requiring meaningful percentages rather than trace amounts.
The Formula
Formulation
Stability
Heat-sensitive above 85°C which can degrade functional phytochemicals. Stable in aqueous solutions within physiological pH range.
Synergies
- Other anti-inflammatory botanicals
- Ceramides for barrier repair
- Hyaluronic acid for hydration
Conflicts
- Strong oxidizing agents
- Highly alkaline environments above pH 8.0
Safety
Safety Profile
NOAEL >5,000 mg/kg established in systemic toxicity studies. Approved by Korean MFDS as non-toxic food material with excellent safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed botanical with demonstrated anti-inflammatory and antioxidant efficacy, particularly beneficial for sensitive and atopic-prone skin.
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References
Sources