Science
Mechanism of Action
Functions primarily by inhibiting matrix metalloproteinases (MMP-1 and MMP-3) that degrade collagen following UV exposure, while simultaneously neutralizing reactive oxygen species through its bioactive compounds including acanthoside D lignans, flavonoids, and polysaccharides that modulate inflammatory pathways including TNF-α and IL-6 cytokines.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 NIH 2023 study demonstrating MMP inhibition and collagen protection in human fibroblasts and hairless mice at derived 0.1% concentration
- 02 PubMed 2015 research showing cytotoxic effects against cancer cells at 50 μg/ml concentration via ROS-dependent mechanisms
Transparency
Dusting Analysis
Given the demonstrated efficacy at 0.1% concentration and the extract's potent bioactive profile, concentrations below 0.001% would likely provide minimal photoprotective benefits
The Formula
Formulation
Stability
Heat-sensitive extract requiring cool-down phase addition below 40°C; compatible with both aqueous and hydro-alcoholic systems due to water-ethanol extraction method
Synergies
- vitamin C
- niacinamide
- hyaluronic acid
Conflicts
- strong oxidizing agents
- high pH formulations above 8.0
Safety
Safety Profile
Listed in IECIC China with global market usage; animal studies indicate low toxicity profile though individual allergic reactions remain possible
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed botanical extract offering targeted photoaging protection through proven MMP inhibition, suitable for universal skin type compatibility.
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References
Sources