Science
Mechanism of Action
Functions through high concentrations of condensed tannins (proanthocyanidins) that reduce IgE-mediated inflammatory responses and provide free radical scavenging activity. The tannin structure also delivers astringent properties that help minimize pore appearance and regulate sebum production while reinforcing barrier integrity.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 Double-blind placebo-controlled study showing significant TEWL reduction and improved skin comfort with oral supplementation
- 02 Mouse model studies demonstrating anti-inflammatory effects and itch reduction in atopic dermatitis conditions
Transparency
Dusting Analysis
While not commonly dusted due to its specialized nature, concentrations below 0.05% are likely insufficient to deliver the documented barrier repair and antioxidant benefits
The Formula
Formulation
Stability
Highly unstable above pH 7.0 where polyflavonoids degrade into inactive phlobaphenes. Requires protection from oxidation and UV exposure through encapsulation or antioxidant inclusion.
Synergies
- Antioxidants (Vitamin C, E)
- Other barrier repair ingredients
- Gentle acids
Conflicts
- Alkaline ingredients
- Strong oxidizing agents
- Proteins
- High salt concentrations
Safety
Safety Profile
Extensive traditional use history with documented safety in both topical and oral applications. Animal studies indicate wide safety margins.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed botanical with proven barrier repair and anti-inflammatory benefits, though formulation challenges limit widespread adoption.
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