Science
Mechanism of Action
Activates the Nrf2 signaling pathway to combat oxidative stress while simultaneously inhibiting ROS-ERK1/2-NLRP3 inflammasomes to reduce inflammation. The extract's flavonoid complex provides dual enzymatic protection by inhibiting hyaluronidase by up to 72% and elastase by up to 42%, preserving dermal matrix integrity and preventing premature aging.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 Human trial (n=51) showed significant T-zone oil reduction and pore size improvement over 6 weeks
- 02 Animal wound healing studies at 6.25-25% concentrations demonstrated accelerated repair and increased collagen density
- 03 In vitro cell viability restoration from 58.7% to 98.1% at 500 μg/mL concentration
Transparency
Dusting Analysis
Given the substantial clinical data showing efficacy at meaningful concentrations (1-25%), dusting concerns are minimal for this botanical extract
The Formula
Formulation
Stability
Demonstrates excellent stability in both aqueous and ethanolic systems. Flavonoid glucosides show superior stability compared to aglycone forms. Ethanol extraction preferred over CO2 for maximum bioactive preservation.
Synergies
- Vitamin C for enhanced antioxidant activity
- Hyaluronic acid for complementary moisture retention
- Niacinamide for additional pore-refining benefits
Conflicts
- Strong oxidizing agents
- Formulations below pH 4.0
Safety
Safety Profile
Extensive traditional use in Chinese medicine supports safety profile. Animal acute toxicity studies show no adverse effects at doses up to 2000 mg/kg body weight.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed botanical extract with proven multi-pathway benefits for skin protection, pore refinement, and barrier repair across all skin types.
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References
Sources