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Moumoujus

8-CYCLOHEXADECENONE.

Optional CAS 3100-36-5 / PERFUMING

A synthetic macrocyclic musk compound traditionally used for fragrance that demonstrates emerging dual functionality in skincare through olfactory receptor activation. This stable ketone molecule activates specific skin receptors (OR2AT4) in keratinocytes and fibroblasts, potentially offering anti-inflammatory benefits beyond its primary perfuming role.

Summary

fragrance anti-inflammatory wound healing support

Science

Mechanism of Action

Functions as an agonist for olfactory receptor OR2AT4 expressed in skin cells, triggering cellular pathways that suppress prostaglandin E2 (PGE2) and interleukin-1 beta (IL-1β) signaling, which may accelerate wound healing and reduce inflammatory responses while providing fragrance fixation.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–6.5%
Optimal

1%

Key findings

  1. 01 Demonstrated reduction in IL-1beta-induced PGE2 release in primary human fibroblasts through OR2AT4 receptor activation

Transparency

Dusting Analysis

Not commonly dusted

Primarily used as a fragrance ingredient rather than an active skincare component, making dusting analysis less applicable for this multifunctional compound.

The Formula

Formulation

Solubility
Oil
Optimal pH 3 – 9
0 7 14

Stability

Exceptionally stable macrocyclic structure resistant to discoloration and pH fluctuations, performs well in both emulsion and alcohol-based systems

Conflicts

  • Strong oxidizing agents
  • Strong acids/bases at elevated temperatures

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
6.5%
Sensitization risk Low

AICIS safety assessment confirms no significant irritation or sensitization up to 6.5%. Some regional guidelines suggest 2% limit for sun-exposed leave-on products. REACH registered but lacks formal CIR review.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Intriguing dual-function ingredient with established safety profile, though anti-inflammatory benefits remain preliminary compared to its proven fragrance applications.

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