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6-NITRO-O-TOLUIDINE.

Avoid CAS 570-24-1 / HAIR DYEING

A nitroaniline derivative primarily functioning as a colorant in semi-permanent hair dye formulations rather than as a skincare active ingredient. This compound works through direct infiltration into hair shafts for temporary coloring, with any skin contact being incidental to its primary hair dyeing purpose.

hair dyeing colorant

Science

Functions as a direct dye through physical infiltration into hair structures without chemical reaction with skin cells. Does not provide established dermatological benefits or biological mechanisms for skin improvement.


Research

Medium confidence
Effective range ≤0.35%
Optimal

0.35%

Key findings

  1. 01 European SCCNFP evaluation confirmed safety at 0.35% maximum concentration in semi-permanent hair formulations
  2. 02 Percutaneous absorption study demonstrated 2.73% absorption rate through human epidermis over 24 hours at 0.69% concentration

Transparency

Not commonly dusted
Red flag below
0.35%

Not used for cosmetic dusting as it serves specialized hair coloring function with strict regulatory concentration limits


The Formula

Solubility
Both
Optimal pH 6.5 – 8
0 7 14

Stability

Photosensitive and air-sensitive compound prone to darkening upon prolonged exposure. Maintains stability in alkaline hair dye bases but degrades at elevated temperatures above 45°C.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Acid anhydrides
  • Chloroformates

Safety

CIR Status
Not reviewed
Max tested
0.35%
Pregnancy
Caution
Sensitization risk Moderate

EU Cosmetic Regulation Annex III restricted ingredient for non-oxidative hair products only. Pure compound exhibits toxicity through multiple exposure routes.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

Specialized hair dye ingredient with no skincare benefits and moderate irritation potential, unsuitable for precision skincare formulations.


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