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Ingredient directory

5-methylfuranone

A dual-action skin brightening compound that inhibits melanin production through two distinct pathways while providing antioxidant protection. Also known as 4-Hydroxy-5-methyl-3(2H)-furanone, this ingredient delivers tyrosinase inhibition comparable to arbutin with added fragrance benefits.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

fragrance flavoring antioxidant skin brightening

Science

Works through a sophisticated dual approach to melanin reduction: first by suppressing tyrosinase gene expression at the mRNA and protein levels, then by directly inhibiting the enzymatic activity of existing tyrosinase enzymes. Additionally provides antioxidant activity to protect against oxidative stress.


Research

Medium confidence
Effective range ≤1%
Optimal

N/A

Key findings

  1. 01 Kyungpook National University study (PMID: 18408869) demonstrating antimelanogenic effects equivalent to arbutin in B16F10 melanoma cells through tyrosinase inhibition

Transparency

Not commonly dusted

Primarily used as a fragrance component with emerging skincare applications; not commonly subject to dusting practices


The Formula

Solubility
Both
Optimal pH 3 – 6
0 7 14

Stability

Exhibits moisture sensitivity and undergoes oxidative degradation at neutral to alkaline pH levels. Demonstrates optimal stability in acidic environments with high solubility in alcohols and glycols (47 g/L in water).

Conflicts

  • Strong oxidizing agents
  • Alkaline pH environments
  • High temperature exposure

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

FEMA GRAS-approved as flavoring agent. RIFM assessments indicate 1.0% maximum concentration in fragrance applications due to potential sensitization at higher levels.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A promising multi-functional ingredient offering clinically-supported skin brightening effects with excellent tolerability across all skin types.


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