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Moumoujus

5-METHYL-5-PHENYL-3-HEXANONE.

Questionable CAS 4927-36-0 / PERFUMING

An aromatic ketone compound that serves as a specialized fragrance ingredient, delivering complex floral, woody, and herbal olfactory profiles to skincare formulations. With high lipophilicity (Log Kow 3.33) and minimal water solubility, this synthetic fragrance component integrates seamlessly into oil-based systems and emulsion oil phases.

Summary

perfuming

Science

Mechanism of Action

Functions purely through olfactory enhancement rather than direct skin physiological activity, providing sensory benefits that distinguish it from traditional active ingredients like retinoids or chemical exfoliants.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

As a fragrance component rather than an active ingredient, dusting analysis is not applicable for this compound.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Exhibits excellent oil solubility with water solubility limited to 70.7-95 mg/L, making it ideal for anhydrous formulations and oil phases of emulsions

Conflicts

  • Strong oxidizing agents
  • Strong bases

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

RIFM assessment establishes NOAEL for fertility at 165 mg/kg/day and NESIL at 1800 μg/cm². Classified as GHS Skin Sensitizer Category 1B with potential for allergic skin reactions. Demonstrates non-mutagenic properties up to 5000 μg/plate in Ames testing.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While effective for fragrance applications, the GHS Category 1B sensitization classification limits its suitability for precision skincare focused on skin health optimization.

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