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5-METHYL-2-PHENYL-2-HEXENAL.

Optional CAS 21834-92-4 / PERFUMING

An alpha,beta-unsaturated aldehyde derivative that serves as a fragrance component, delivering distinctive cocoa and chocolate aromatic notes to cosmetic formulations. While primarily valued for its olfactory properties, preliminary research suggests potential antioxidant and anti-inflammatory activities, though these mechanisms remain secondary to its perfuming function in skincare applications.

perfuming

Science

Functions predominantly through olfactory enhancement rather than direct skin biochemical activity, providing sensory appeal that may influence user experience and product perception, with possible minor antioxidant contributions from its aldehyde structure.


Research

Medium confidence
Effective range 0.1–8%
Optimal

N/A

Key findings

  1. 01 90-day subchronic oral toxicity study in F344 rats demonstrated safety at standard usage concentrations (Ogawa K et al., 2021)

Transparency

Not commonly dusted

As a fragrance component rather than active ingredient, dusting practices are not typically relevant for this compound


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Demonstrates high stability across various solvent systems but requires protection from light, heat, and atmospheric oxygen due to aldehyde group oxidation susceptibility

Conflicts

  • Strong oxidizing agents
  • Strong bases (aldol condensation risk)
  • Primary amines (Schiff base formation potential)

Safety

CIR Status
Not reviewed
Max tested
8%
Sensitization risk Moderate

FEMA GRAS status for food applications (FEMA 3199), IFRA-compliant at ≤8% in fragrance concentrates, classified as skin and eye irritant with allergic reaction potential


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Optional

A specialized fragrance ingredient that enhances sensory experience but offers limited direct skin benefits and requires careful formulation due to moderate irritation potential.


Related

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References