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Moumoujus

5-HEXEN-2-ONE.

Optional CAS 109-49-9 / PERFUMING

A volatile organic ketone primarily used as a fragrance component in cosmetic formulations, providing a subtle cooling sensation through TRPM8 receptor modulation. This non-reactive compound demonstrates excellent stability across diverse pH conditions but carries moderate irritation potential for sensitive skin types.

Summary

perfuming cooling agent

Science

Mechanism of Action

Functions primarily as an olfactory agent while offering secondary cooling effects via TRPM8 receptor interaction. As a non-reactive ketone, it does not form covalent bonds with skin proteins, maintaining its volatile aromatic properties without significant biochemical transformation.

Research

Clinical Evidence

Medium confidence
Effective range ≤2%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Typically incorporated within fragrance blends rather than listed individually, making dusting assessment less relevant for this aromatic component.

The Formula

Formulation

Solubility
Both
Optimal pH 2 – 12
0 7 14

Stability

Demonstrates remarkable pH tolerance from acidic to alkaline conditions with flash point concerns at 23°C requiring careful storage protocols.

Conflicts

  • Strong bases
  • Reducing agents
  • Oxidizing materials

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

ECHA classification includes skin irritant designation (H315) with RIFM validation for current fragrance concentrations showing minimal sensitization risk below established thresholds.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Optional

A stable fragrance ingredient with cooling properties suitable for non-sensitive skin applications within established concentration limits.

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