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5-CYCLOHEXADECENONE.

Optional CAS 37609-25-9 / PERFUMING

A macrocyclic ketone compound engineered as a high-performance fragrance ingredient with exceptional longevity, providing up to 400 hours of scent substantivity. Unlike active skincare ingredients, this synthetic musk serves purely as an olfactory enhancer, delivering a powdery musk profile without biological activity on skin tissue. Its stable molecular structure makes it a reliable choice for maintaining consistent fragrance performance across diverse cosmetic formulations.

perfuming

Science

Functions exclusively through olfactory receptor binding rather than dermal penetration or cellular interaction. The macrocyclic structure enables prolonged fragrance release without inducing physiological changes in skin barrier function, cellular metabolism, or tissue repair processes.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

As a fragrance-only ingredient with no therapeutic claims, dusting is not applicable to this compound's primary function


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Exhibits superior thermal and chemical stability compared to traditional musk compounds, resisting discoloration and degradation in alkaline conditions including soaps and detergents


Safety

CIR Status
Not reviewed
Max tested
4%
Sensitization risk Low

IFRA-regulated at 4% maximum for fragrance applications. Toxicological data shows low systemic toxicity (LD50 > 2000 mg/kg) with potential for mild irritation only at concentrations exceeding recommended limits


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A technically proficient fragrance ingredient with no skincare benefits, suitable for scented formulations where prolonged musk notes are desired.


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