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5,5,6-TRIMETHYLBICYCLOHEPT-2-YLCYCLOHEXANOL.

Questionable CAS 3407-42-9 / PERFUMING

A synthetic aromatic compound that delivers a distinctive woody, sandalwood-like fragrance profile in cosmetic formulations. While effective as a fragrance ingredient, it carries notable sensitization risks and has been linked to pigmented dermatitis in clinical reports from Japan.

perfuming

Science

Functions exclusively as an olfactory enhancer, providing woody fragrance notes to cosmetic products. In susceptible individuals, it can trigger inflammatory cascades leading to allergic contact dermatitis or photosensitivity reactions through hapten formation with skin proteins.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Documented cases of pigmented cosmetic dermatitis in Japanese population studies
  2. 02 Photosensitivity and allergic contact dermatitis in fragrance mixture testing

Transparency

Not commonly dusted

Used exclusively for fragrance purposes at extremely low concentrations (0.000097% typical), making dusting practices irrelevant for this aromatic compound.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Maintains stability under standard cosmetic storage conditions. Requires dilution in carrier solvents such as Isopropyl Myristate or Dipropylene Glycol for proper incorporation.

Conflicts

  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
0.1%%
Sensitization risk High

Regulated under IFRA fragrance safety standards. Safety data sheets flag potential for skin sensitization and ocular irritation. Clinical reports document pigmented dermatitis cases.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

While effective as a woody fragrance note, documented sensitization risks and pigmented dermatitis cases make this ingredient problematic for precision skincare applications.


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