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4-THUJANOL.

Optional CAS 546-79-2 / PERFUMING

A bicyclic monoterpenoid alcohol primarily used as a fragrance component with mild penetration enhancement properties. This volatile compound provides subtle cooling sensations while offering antimicrobial benefits, though its primary role in skincare remains limited to scenting and masking applications.

perfuming masking antimicrobial penetration enhancer

Science

Disrupts stratum corneum lipid bilayers to enhance ingredient penetration while providing mild analgesic cooling effects and antimicrobial activity through its monoterpenoid structure


Research

Medium confidence
Effective range 0.02–0.5%
Optimal

0.02%

Key findings

  1. 01 Safe exposure levels below toxicological concern thresholds with no sensitization risk

Transparency

Not commonly dusted

Primarily used as a fragrance component at very low concentrations, not typically subject to misleading marketing claims


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Highly volatile requiring cool, dark storage conditions; stable in anhydrous and oil-based systems but degrades with heat exposure

Conflicts

  • Strong oxidizing agents
  • High heat exposure

Safety

CIR Status
Not reviewed
Max tested
0.5%
Sensitization risk Low

RIFM and IFRA recommend maximum 0.5% in fragrance concentrates; in vitro genotoxicity observed at higher concentrations but no concern at typical use levels


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A specialized fragrance ingredient with minor functional benefits that's safe at low concentrations but offers limited skincare value beyond scenting.


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