Science
Mechanism of Action
Functions as a selective antagonist of TRPV1 receptors on sensory nerve fibers, effectively raising the skin's tolerance threshold and preventing the transmission of pain and irritation signals before they can trigger inflammatory cascades.
Research
Clinical Evidence
High confidence0.4%
Key findings
- 01 Randomized trial (n=31) showed 78-80% reduction in capsaicin-induced burning within 3 minutes at 0.4% concentration
- 02 Large-scale study (n=1,221) demonstrated significant improvement in rosacea symptoms after 4 weeks at 1.0% concentration
- 03 Asian population study revealed 65% reduction in hypersensitivity scores over 21 days
Transparency
Dusting Analysis
IFRA restricts to 0.038% for fragrance use due to sensitization concerns, but functional soothing applications safely use up to 1.0% with clinical validation
The Formula
Formulation
Stability
Demonstrates robust stability across standard cosmetic pH ranges as a cyclic ketone derivative, with minimal water solubility but excellent compatibility with glycols and lipid phases
Synergies
- Licochalcone A
- Pentylene Glycol
Conflicts
- Strong oxidizing agents
- Strong acids
Safety
Safety Profile
Evaluated by RIFM for fragrance safety with concentration-dependent restrictions, but clinical literature supports higher levels for therapeutic soothing applications
Your Skin
Skin Compatibility
Our Assessment
Verdict
Clinically-proven neurosensory modulator that delivers measurable relief for sensitive and reactive skin conditions with excellent safety profile.
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References
Sources