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Moumoujus

4-METHYLPENT-3-EN-2-ONE.

Questionable CAS 141-79-7 / PERFUMING

Also known as Mesityl Oxide, this alpha-beta unsaturated ketone functions primarily as a fragrance component in cosmetics, delivering distinctive honey and peppermint olfactory notes. Despite being GRAS-approved for food flavoring, its classification as a GHS Category 2 skin and eye irritant severely limits its cosmetic applications beyond minimal fragrance use.

Summary

perfuming

Science

Mechanism of Action

Functions as a Michael acceptor that can react with skin proteins through Michael addition chemistry, which represents the primary molecular pathway for potential skin sensitization rather than beneficial skincare activity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Limited to fragrance applications at minimal concentrations due to irritancy profile

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Exhibits high volatility with 130°C boiling point and photosensitivity leading to darkening over time. Water solubility limited to approximately 3% at 20°C while showing complete miscibility with ethanol and oils.

Conflicts

  • Oxidizing agents
  • Strong acids
  • Strong bases

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Classified as GHS Category 2 Skin Irritant and Category 2 Eye Irritant with documented Michael addition electrophile activity contributing to sensitization potential.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While acceptable for minimal fragrance use, the significant irritancy and sensitization risks outweigh any cosmetic benefits for precision skincare applications.

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