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4-FORMYL-1-METHYLQUINOLINIUM-P-TOLUENESULFONATE.

Questionable CAS 223398-02-5 / HAIR DYEING

A quinolinium-based chemical intermediate primarily designed for oxidative hair coloring systems. This synthetic compound functions as a dye precursor that requires oxidative activation to form colored pigment molecules within hair keratin structures.

hair dyeing color formation oxidative coupling agent

Science

Functions as a coupling agent in oxidative hair dye formulations, reacting with hydrogen peroxide and other intermediates to create large, stable pigment molecules that become permanently trapped within hair fiber structures


Research

High confidence
Effective range 0.5–2.5%
Optimal

2.5%


Transparency

Not commonly dusted
Red flag below
2.5%

Regulatory maximum established at 2.5% for hair applications; not intended for general skincare formulations


The Formula

Solubility
Water
Optimal pH 4.8 – 9.5
0 7 14

Stability

Demonstrates excellent stability in aqueous systems and DMSO for 48+ hours with >96% recovery; requires oxidative environment for activation

Synergies

  • Hydrogen peroxide
  • Other oxidative hair dye intermediates

Conflicts

  • Reducing agents
  • Strong alkaline conditions above pH 9.5
  • Non-oxidative formulation environments

Safety

CIR Status
Not reviewed
Max tested
2.5%
Sensitization risk Low

EU regulated under Annex III/274; confirmed eye irritant with moderate skin irritation potential; non-sensitizing in LLNA testing but requires allergy warnings for hair dye applications


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Specialized hair dye intermediate with no established skincare benefits and moderate irritation potential.


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