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4-ETHYLBENZALDEHYDE.

Questionable CAS 4748-78-1 / PERFUMING

A fragrant aldehyde compound used exclusively as a perfuming agent in cosmetic formulations. While it provides pleasant scent characteristics, this ingredient carries notable sensitization concerns that limit its use in skincare products.

perfuming

Science

Functions purely as a sensory additive by providing fragrance to cosmetic products. As an aldehyde compound, it can interact with skin proteins through chemical reactions, which may trigger allergic sensitization responses in susceptible individuals.


Research

Medium confidence
Effective range ≤0.51%
Optimal

N/A

Key findings

  1. 01 RIFM safety assessment established No Expected Sensitization Induction Level of 1100 μg/cm² through read-across analysis
  2. 02 Zebrafish toxicity studies at 0.11% concentration showed DNA damage and liver effects after 21-day exposure

Transparency

Not commonly dusted
Red flag below
0.12%

IFRA regulations strictly limit concentrations due to sensitization risks, making dusting unnecessary and potentially harmful


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Stable under ambient conditions but requires controlled storage at 10-25°C in sealed containers. Avoid exposure to oxidizing conditions.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Strong reducing agents

Safety

CIR Status
Not reviewed
Max tested
0.51%
Sensitization risk Moderate

IFRA-regulated with category-specific limits: 0.12% for facial moisturizers and body lotions, 0.51% for fingertip-applied products. Zebrafish studies indicate potential genotoxic effects at higher concentrations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

While effective as a fragrance component, the sensitization risks and regulatory restrictions make it a questionable choice for precision skincare formulations.


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