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4-ETHOXY-M-PHENYLENEDIAMINE.

Avoid CAS 5862-77-1 / HAIR DYEING

A synthetic aromatic amine compound primarily utilized as an oxidative coupler in permanent hair coloring systems. This ingredient works by penetrating hair fibers and forming stable color complexes through oxidative reactions, though it carries significant sensitization concerns for skincare applications.

hair dyeing

Science

Functions as a reactive precursor that undergoes oxidation to create large pigment molecules within hair shafts. On skin contact, it can bind to proteins and trigger immune responses, potentially leading to allergic contact dermatitis in susceptible individuals.


Research

Medium confidence
Effective range ≤10%
Optimal

N/A

Key findings

  1. 01 CIR Expert Panel evaluation demonstrated skin sensitization potential but confirmed safety for hair dye use up to 10% concentration in non-sensitized individuals

Transparency

Not commonly dusted

Not applicable for skincare formulations due to sensitization risks and primary function as hair dye component


The Formula

Solubility
Water
Optimal pH 7 – 10
0 7 14

Stability

Exhibits high stability in sulfate salt form but degrades when exposed to air oxidation and light. Maintains optimal stability under alkaline conditions.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Acid chlorides
  • Acid anhydrides

Safety

CIR Status
Safe with restrictions
Max tested
10%
Sensitization risk High

Restricted to hair dye applications only, prohibited for use on eyelashes and eyebrows. Known potent skin sensitizer requiring careful handling.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

Unsuitable for precision skincare due to high sensitization potential and restriction to hair dye applications only.


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