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4-DIMETHYLMETHYLENECYCLOHEXYL-BUTAN-2-ONE.

Valuable CAS 13720-12-2 / PERFUMING

A bio-fermented sesquiterpene lactone derived from clary sage that functions as an advanced brightening agent with exposome protection. This ingredient targets multiple pathways of hyperpigmentation while defending against environmental stressors including UV radiation, blue light, and urban pollution.

skin brightening soothing antioxidant fragrance

Science

Inhibits tyrosinase enzyme activity to reduce melanin synthesis while simultaneously blocking inflammatory signaling pathways triggered by environmental aggressors. Functions as a dual-action brightener that both prevents new pigmentation formation and soothes existing skin irritation from pollution and light exposure.


Research

High confidence
Effective range 0.1–1%
Optimal

0.2%

Key findings

  1. 01 Significantly reduced UV-induced pigmentation and maintained skin brightness compared to placebo in Asian subjects (Phototypes II-III)
  2. 02 Demonstrated tyrosinase inhibition in human epidermal melanoma cells with protection against blue light and pollution-induced hyperpigmentation

Transparency

Not commonly dusted
Min. effective
0.05%
Red flag below
0.05%

With proven efficacy at 0.2% and typical use ranges of 0.1-0.5%, concentrations below 0.05% would likely provide minimal brightening benefits


The Formula

Solubility
Oil
Optimal pH 3 – 8
0 7 14

Stability

Exceptional thermal and photostability with minimal degradation upon air or light exposure. Crystalline powder form maintains integrity across wide pH range.

Synergies

  • antioxidants
  • other tyrosinase inhibitors
  • sunscreen actives

Conflicts

  • strong oxidizing agents
  • highly alkaline formulations above pH 9

Safety

CIR Status
Not reviewed
Max tested
1%
Pregnancy
Safe
Sensitization risk Low

Generally recognized as safe at typical cosmetic concentrations. China-compliant and positioned as gentler alternative to traditional brightening agents like kojic acid.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Well-researched brightening ingredient with unique exposome protection and excellent safety profile across all skin types.


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