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4-DIHYDROMETHYL-2H-PYRAN-2-YL GUAIACOL.

Optional CAS 128489-02-1 / PERFUMING

A synthetic fragrance compound that delivers woody, spicy aromatic notes to skincare and cosmetic formulations. While primarily functioning as a perfuming agent, its guaiacol-derived structure suggests potential mild antioxidant activity through phenolic hydrogen donation.

perfuming

Science

Functions primarily as a fragrance component providing sensory benefits through olfactory enhancement. The phenolic hydroxyl group may contribute minor antioxidant effects by neutralizing free radicals, though this secondary function is not well-established in skincare applications.


Research

Medium confidence
Effective range 0.04–0.4%
Optimal

N/A

Key findings

  1. 01 AICIS safety evaluation at 0.04-0.4% in consumer products shows no significant public health concerns
  2. 02 RIFM assessment indicates sensitization rates of 0.12% or lower in human repeat insult patch test subjects

Transparency

Not commonly dusted

Used at functional concentrations below 0.4% for fragrance purposes rather than as an active ingredient requiring dusting analysis


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Viscous liquid stable under normal conditions but decomposes at high temperatures (266-271°C). Water-insoluble but readily dissolves in alcohol and organic solvents typical of fragrance oils.

Conflicts

  • Strong oxidizing agents

Safety

CIR Status
Not reviewed by CIR
Max tested
0.4%
Sensitization risk Low

Evaluated by RIFM and IFRA for fragrance safety. Australian regulatory assessment confirms safety at typical use concentrations. May cause sensitization in fragrance-sensitive individuals despite low overall incidence.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient with established safety data but limited skincare benefits beyond sensory enhancement.


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