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Moumoujus

4-BUTYLRESORCINOL.

Valuable CAS 18979-61-8 / ANTIOXIDANT

A potent tyrosinase inhibitor that demonstrates superior melanin suppression compared to hydroquinone and kojic acid. Clinical trials show measurable improvements in melasma and post-inflammatory hyperpigmentation at concentrations as low as 0.1%. This competitive enzyme inhibitor offers a gentler alternative for targeted pigmentation correction with excellent tolerability profiles.

Summary

skin-brightening antioxidant tyrosinase inhibitor

Science

Mechanism of Action

Competitively inhibits tyrosinase and tyrosinase-related protein-1 by binding to their active sites, blocking the conversion of L-tyrosine to L-DOPA and preventing subsequent melanin synthesis cascade

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

0.3%

Key findings

  1. 01 Randomized split-face trial demonstrated 4.87% melanin index reduction versus 2.21% increase in placebo within 8 weeks
  2. 02 84% response rate in melasma treatment with excellent tolerability in Indian population study

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.03%

Effective concentrations start at 0.1% with clinical validation; formulations below 0.05% likely provide minimal pigmentation benefits

The Formula

Formulation

Solubility
Both
Optimal pH 4.5 – 6.5
0 7 14

Stability

Requires careful oxidation protection through antioxidants or encapsulation technologies; light sensitivity demands opaque packaging

Synergies

  • sodium metabisulfite
  • vitamin C
  • niacinamide

Conflicts

  • strong oxidizing agents
  • iron ions
  • alkaline pH environments

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

Generally well-tolerated in clinical studies with minimal irritation reported; lacks formal regulatory review but widely accepted in cosmetic applications

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Clinically-proven tyrosinase inhibitor offering effective pigmentation control with superior tolerability compared to traditional brightening agents.

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