Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

4-BUTYL-5-METHYLTHIAZOLE.

Optional CAS 57246-60-3 / PERFUMING

A specialized thiazole derivative primarily employed as a fragrance component and mild antioxidant in premium anti-aging formulations. This aromatic compound contributes green, bell pepper-like notes while providing secondary stability benefits through its radical-scavenging properties.

fragrance masking agent antioxidant

Science

Functions predominantly as a sensory modifier, masking unwanted odors while imparting subtle fragrance notes. The thiazole ring structure offers modest antioxidant activity by neutralizing free radicals, potentially contributing to formulation stability rather than direct skin benefits.


Research

Low confidence
Effective range 0.01–0.01%
Optimal

0.01%

Key findings

  1. 01 Established olfactory threshold concentration for sensory applications

Transparency

Not commonly dusted

Used at extremely low concentrations (0.01%) for fragrance purposes, making dusting unlikely and irrelevant for this application.


The Formula

Solubility
Oil
Optimal pH 3 – 7
0 7 14

Stability

Exhibits high stability due to aromatic thiazole structure, though susceptible to color changes (colorless to yellow-brown) under extreme oxidative conditions. pKa approximately 3.27.

Conflicts

  • Strong oxidizing agents
  • Nitrosating agents

Safety

CIR Status
Not reviewed
Sensitization risk Low

FDA registered (UNII: 6SMO0I83KL). Related thiazole compounds assessed by RIFM show safety at concentrations below 0.01% in leave-on products.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A niche ingredient offering fragrance benefits with minimal direct skincare impact, suitable for luxury formulations requiring sensory refinement.


Related

Finding similar ingredients…


References