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4-AMINO-3-HYDROXYBUTYRIC ACID.

Valuable CAS 924-49-2 / SKIN CONDITIONING

A GABA-derived amino acid that functions as a neuromodulator in skincare, targeting expression lines through gentle muscle relaxation mechanisms. Known by its scientific abbreviation GABOB, this ingredient offers a non-invasive approach to addressing facial tension while providing anti-inflammatory benefits for sensitive skin conditions.

Skin-conditioning Soothing Moisturizing Anti-aging

Science

Functions as a GABAB receptor agonist to modulate neurotransmitter activity in facial muscles, reducing micro-contractions that contribute to expression lines. Simultaneously suppresses pro-inflammatory cytokine release, creating a dual action that relaxes facial tension while calming skin barrier stress responses.


Research

Medium confidence
Effective range 0.1–1%
Optimal

0.5%


Transparency

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Patent data shows activity ranges from 0.0001% to 50%, but clinical efficacy requires minimum 0.1% concentration for meaningful neuromodulation effects


The Formula

Solubility
Water
Optimal pH 4 – 6
0 7 14

Stability

Exhibits excellent stability in aqueous systems with sensitivity to extreme pH fluctuations. Maintains integrity in refrigerated storage and shows compatibility with glycol-based co-solvents.

Synergies

  • Other amino acids
  • DMSO
  • Glycols

Conflicts

  • Strong oxidizing agents
  • High-concentration anionic surfactants

Safety

CIR Status
Safe as used
Max tested
1%
Pregnancy
Safe
Sensitization risk Low

FDA recognizes as GRAS for oral consumption in supplement form. Topical application shows non-irritating profile within cosmetic concentration ranges.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A scientifically-backed neuromodulating amino acid that offers gentle, non-invasive expression line management with excellent safety profile across all skin types.


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