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Moumoujus

4-AMINO-2-NITROPHENOL.

Avoid CAS 119-34-6 / HAIR DYEING

A substituted aromatic amine primarily used as a direct hair colorant with demonstrated penetration capabilities through skin barriers. While classified as a semi-permanent dye component, this ingredient has raised regulatory concerns due to insufficient safety data for cosmetic applications.

Summary

hair dyeing colorant

Science

Mechanism of Action

Functions as a direct-deposit colorant that penetrates hair shafts and skin tissue through its aromatic amine structure, with potential for systemic absorption and contact sensitization responses

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 NTP bioassays revealed limited carcinogenicity evidence in male rats (renal-cell adenomas), with no tumor increases in mice or female subjects

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
2%

Not typically used for dusting purposes; regulatory restrictions and safety concerns limit its cosmetic applications

The Formula

Formulation

Solubility
Both
Optimal pH 7 – 9.5
0 7 14

Stability

Maintains stability at ambient temperature but degrades when exposed to air oxidation; requires controlled alkaline environment for reduction processes

Conflicts

  • strong oxidizing agents
  • strong bases
  • acid chlorides
  • acid anhydrides
  • cellulose-based absorbents

Safety

Safety Profile

CIR Status
Insufficient data
Pregnancy
Caution
Sensitization risk Moderate

CIR Expert Panel requires additional dermal penetration and reproductive toxicity studies; banned in EU hair dye formulations under Annex II restrictions

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Regulatory restrictions and insufficient safety data make this ingredient unsuitable for precision skincare applications.

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References

Sources