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4,6-BIS(2-HYDROXYETHOXY)-M-PHENYLENEDIAMINE.

Insufficient Data / HAIR DYEING

A specialized meta-diamine coupler primarily used in oxidative hair coloring systems to create dark brown and black tones. This ingredient undergoes oxidative polymerization with primary intermediates in the presence of hydrogen peroxide to form permanent color pigments within the hair shaft.

hair dyeing

Science

Acts as a secondary intermediate in oxidative hair dye chemistry, reacting with primary intermediates like p-phenylenediamine under alkaline conditions to create large chromophore molecules that deposit color permanently in hair


Research

High confidence
Effective range 0.1–2%
Optimal

2%

Key findings

  1. 01 SCCS safety evaluation confirmed appropriate use as hair dye coupler at maximum 2.0% concentration with hydrogen peroxide systems

Transparency

Not commonly dusted

This ingredient is exclusively used in hair coloring applications and is not applicable to general skincare formulations


The Formula

Solubility
Water
Optimal pH 8 – 10
0 7 14

Stability

Exhibits high air sensitivity requiring storage as hydrochloride salt form; demands alkaline environment for optimal coupling reactions and operational stability

Synergies

  • hydrogen peroxide
  • p-phenylenediamine
  • alkaline activators

Conflicts

  • oxidizing agents (pre-use)
  • nitrosating agents
  • strong acids
  • halogenated organics

Safety

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Moderate

SCCS 2024 opinion validates 2% maximum on-head concentration; presents moderate skin sensitization potential and possible eye irritation


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Insufficient Data

Specialized hair dye ingredient with no established skincare applications or benefits for facial skin treatment.


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