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4,4'-DIAMINODIPHENYLAMINE.

Avoid CAS 537-65-5 / HAIR DYEING

A specialized chemical intermediate primarily used in oxidative hair dye formulations rather than skincare applications. This compound functions as a coupling agent that reacts with hydrogen peroxide to create permanent color molecules within hair fibers.

Hair dyeing

Science

Acts as a precursor molecule in oxidative hair coloring systems, undergoing chemical transformation when exposed to alkaline conditions and oxidizing agents to form large pigment complexes, but provides no direct skincare benefits such as hydration or anti-aging effects.


Research

Medium confidence
Effective range ≤0.2%
Optimal

N/A

Key findings

  1. 01 Deemed safe for consumer use in hair dye applications at concentrations not exceeding 0.2%

Transparency

Not commonly dusted

Not applicable for skincare formulations as this ingredient is restricted to hair dye applications only


The Formula

Solubility
Water
Optimal pH 8 – 10
0 7 14

Stability

Extremely unstable when exposed to light and oxygen, rapidly oxidizing from white to dark brown/black coloration; requires alkaline environment for intended function

Conflicts

  • Strong oxidizing agents before application
  • Strong acids
  • Nitrosating compounds due to N-nitroso formation risk

Safety

CIR Status
Safe with restrictions - hair dye use only
Max tested
0.2%
Sensitization risk Moderate

Recognized as potential skin sensitizer; safety evaluation limited to hair dye applications; listed as restricted substance under EU Annex III


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

Inappropriate for skincare formulations as this ingredient is specifically restricted to hair dye applications and offers no skincare benefits.


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