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3-METHYLAMINO-4-NITROPHENOXYETHANOL.

Optional CAS 59820-63-2 / HAIR DYEING

A nitrophenol-derived direct dye compound that primarily functions as a semi-permanent hair colorant by depositing pigment onto the hair cuticle. This synthetic aromatic ingredient demonstrates low skin penetration rates and minimal irritation potential in clinical evaluations.

hair dyeing colorant

Science

Functions as a direct-depositing colorant that adheres to external surfaces rather than penetrating deeply into tissues, with studies showing only 0.42% percutaneous absorption of applied doses


Research

High confidence
Effective range 0.15–1%
Optimal

0.15%

Key findings

  1. 01 CIR safety assessment at 0.15% maximum use concentration in hair dye formulations
  2. 02 Human skin penetration study demonstrating 0.42% absorption rate
  3. 03 Murine LLNA testing showing non-sensitizing properties at 2.0% concentration

Transparency

Not commonly dusted

Primarily used in hair care applications with established safety thresholds; not commonly found in misleading concentrations


The Formula

Solubility
Water
Optimal pH 3 – 10
0 7 14

Stability

Maintains stability in aqueous cosmetic bases but shows sensitivity to strong reducing agents which can cause color degradation

Conflicts

  • Strong reducing agents
  • Strong oxidizing agents

Safety

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

CIR Panel concludes safety at current use practices up to 0.15%; EU SCCS authorizes up to 1.0% in finished products


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A specialized hair colorant with established safety profile but limited skincare applications due to its primary function as a direct dye.


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