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3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)METHYL)CYCLOHEXANOL.

Valuable CAS 71820-51-4 / PERFUMING

A synthetic sandalwood-derived compound that functions as both a fragrance component and active skin regenerating ingredient. This molecule uniquely activates specialized olfactory receptors present in skin cells, triggering cellular repair processes that accelerate wound healing and skin renewal.

perfuming skin regenerating

Science

Functions as a selective agonist for the OR2AT4 olfactory receptor expressed in human keratinocytes, initiating calcium-dependent signaling cascades that activate MAPK/ERK and p38 pathways to enhance cellular proliferation and migration for improved re-epithelialization


Research

Medium confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 Demonstrated activation of skin keratinocyte olfactory receptors leading to enhanced cell proliferation and migration for accelerated wound healing

Transparency

Not commonly dusted

Primary use as fragrance component with emerging skincare applications makes dusting unlikely


The Formula

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

Exhibits exceptional stability in lipid-based formulations and emulsion systems with superior oxidation resistance compared to natural essential oils due to its secondary alcohol structure

Conflicts

  • Strong oxidizing agents
  • Strong acids

Safety

CIR Status
Not reviewed
Max tested
1.2%
Sensitization risk Low

Regulated under IFRA standards as fragrance ingredient with lower allergenicity profile than natural sandalwood oil, restricted to 1.2% maximum in leave-on products


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Innovative dual-function ingredient offering validated skin regeneration benefits through novel olfactory receptor activation with excellent safety profile.


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