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3-METHYL-4-(3,5,6-TRIMETHYL-3-CYCLOHEXENYL)-3-BUTEN-2-ONE.

Questionable CAS 67801-31-4 / PERFUMING

A synthetic fragrance molecule, also known as Alpha-Isomethyl Ionone, that delivers violet-floral notes to cosmetic formulations. This unsaturated ketone serves purely sensory purposes with no bioactive skin benefits, but carries notable allergenicity concerns that require careful consideration in precision skincare.

perfuming

Science

Functions exclusively as an olfactory receptor ligand, binding to scent receptors to produce characteristic violet/floral/powdery fragrance notes. In sensitized individuals, acts as a hapten that conjugates with skin proteins, triggering Type IV delayed hypersensitivity reactions and potential allergic contact dermatitis.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted
Min. effective
0.001%
Red flag below
0.2%

EU regulations mandate disclosure above 0.001% in leave-on products due to allergenic potential. Concentrations above 0.2% showed zero sensitization in clinical trials, but higher concentrations demonstrated 9.1% sensitization rates.


The Formula

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Demonstrates superior stability compared to natural fragrance alternatives. Susceptible to oxidative degradation when exposed to air and UV light, though significantly more stable than citrus terpenes.

Conflicts

  • Strong oxidizing agents
  • Strong acids and alkalis
  • High UV exposure conditions

Safety

CIR Status
Safe with restrictions
Max tested
13%
Sensitization risk Moderate

IFRA permits up to 7.6% in facial moisturizers and 30-32% in fine fragrances. Clinical data shows 9.1% sensitization rate at 2.0% concentration, with 0.26-0.79% of eczema patients showing positive patch test reactions.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Questionable

While functionally effective as a fragrance component, the moderate sensitization risk and lack of skin benefits make it questionable for precision skincare focused on skin health optimization.


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