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3-ISOPENTENYL ISOVALERATE.

Optional CAS 54410-94-5 / PERFUMING

A naturally-occurring ester compound found in essential oils like Artemisia annua and marula fruit, primarily utilized as a fragrance ingredient in skincare formulations. This volatile compound demonstrates high predicted skin permeability (LogKp > -7.0) and may offer minor emollient properties while contributing to botanical extract efficacy through enhanced penetration support.

perfuming emollient

Science

Functions primarily as a perfuming agent with its volatile, lipophilic structure allowing efficient scent delivery. As an ester compound, it provides subtle emollient benefits to skin barrier function and may facilitate the penetration of other active botanical compounds due to its favorable permeability profile.


Research

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Identified in Artemisia annua essential oil research showing antimicrobial, anti-inflammatory, and antioxidant properties (Molecules 2023)
  2. 02 Cryptocarya alba extract studies suggest anti-inflammatory potential with high skin permeability prediction (PMC 2025)

Transparency

Not commonly dusted

Used at functional fragrance levels rather than inflated concentrations for marketing purposes


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Susceptible to hydrolysis at extreme pH levels, breaking down into isopentenyl alcohol and isovaleric acid. Maintains stability in typical cosmetic pH ranges but requires protection from excessive heat exposure.

Synergies

  • botanical extracts
  • essential oil blends
  • other fragrance compounds

Conflicts

  • Strong oxidizing agents
  • Strongly alkaline environments (pH > 9.0)
  • Strongly acidic environments (pH < 3.0)

Safety

CIR Status
Not reviewed
Sensitization risk Low

Listed in EU CosIng database and subject to IFRA fragrance material standards requiring adherence to purity and sensitization limits


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A functional fragrance ingredient with potential minor skin benefits but limited standalone clinical evidence for significant skincare efficacy.


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References