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3-HYDROXYBUTYRIC ACID.

Valuable CAS 625-72-9 / ANTI-SEBUM, HUMECTANT, PLASTICISER

A naturally occurring beta-hydroxy acid that serves as a gentler alternative to salicylic acid, offering exfoliation benefits while maintaining humectant properties. This biocompatible metabolite demonstrates impressive antibacterial efficacy against resistant strains while supporting skin barrier repair and wound healing processes.

Exfoliant Humectant Anti-inflammatory Antibacterial

Science

Functions as a beta-hydroxy acid by disrupting ionic bonds between corneocytes to promote gentle desquamation. Simultaneously suppresses inflammatory pathways through NLRP3 inflammasome inhibition, reducing IL-1β production while providing antioxidant protection and supporting collagen synthesis against UV-induced damage.


Research

Medium confidence
Effective range 0.625–2%
Optimal

1%

Key findings

  1. 01 99.97% antibacterial efficacy against MRSA at 0.625% concentration with wound healing support
  2. 02 Effective exfoliation and anti-aging benefits observed in 1.0-2.0% range typical for beta-hydroxy acids

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Given its potent antibacterial activity at 0.625%, concentrations below 0.1% would likely provide minimal therapeutic benefit beyond basic humectant properties


The Formula

Solubility
Water
Optimal pH 3.5 – 5.5
0 7 14

Stability

Demonstrates excellent stability in aqueous solutions at physiological pH ranges (6.0-8.0), with optimal activity selectivity at pH 5.5

Synergies

  • Niacinamide
  • Hyaluronic acid
  • Ceramides

Conflicts

  • Strong oxidizers
  • Strong bases
  • Strong acids

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

As a natural human metabolite, shows excellent biocompatibility profile. While not specifically CIR-reviewed, related BHAs have 10% consumer use limits established


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A promising multi-functional BHA offering gentle exfoliation with superior antibacterial properties and broad skin type compatibility.


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