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3-HYDROXYBENZOIC ACID.

Valuable CAS 99-06-9 / SKIN CONDITIONING

A gamma-hydroxy acid that offers gentle yet effective chemical exfoliation with enhanced skin tolerance compared to traditional alpha-hydroxy acids. This versatile ingredient combines exfoliating benefits with antioxidant protection, making it suitable for addressing multiple skin concerns including texture irregularities, fine lines, and photodamage.

skin conditioning exfoliant antioxidant

Science

Functions as a gamma-hydroxy acid by disrupting intercellular bonds between keratinocytes in the stratum corneum to accelerate cellular turnover. Simultaneously provides antioxidant protection through free radical scavenging and inhibition of matrix metalloproteinases and reactive oxygen species, supporting collagen preservation.


Research

Medium confidence
Effective range 0.1–20%
Optimal

2.5%

Key findings

  1. 01 Patent study demonstrating improved skin texture, luminosity, and reduced appearance of fine lines and pigmentation at 0.5-10% with lower irritation versus AHAs
  2. 02 Concentration range study showing effectiveness from 0.01-30% for photodamage treatment, with professional treatments utilizing up to 30%

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Given the established effective range starting at 0.1% for daily cosmetic use, concentrations below this threshold may indicate dusting rather than therapeutic dosing.


The Formula

Solubility
Both
Optimal pH 3 – 4.5
0 7 14

Stability

Exceptionally thermally stable up to 300°C and resistant to decarboxylation unlike other hydroxybenzoic acid isomers. Limited water solubility at 7.25 mg/mL but highly soluble in ethanol and glycols.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Iron salts

Safety

CIR Status
Not reviewed
Max tested
30%
Sensitization risk Low

FDA-approved as flavoring agent (FEMA 4431) and EU CosIng database classified for skin conditioning. Patent literature indicates superior tolerability profile compared to glycolic and salicylic acids.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A well-tolerated multi-functional ingredient that delivers effective exfoliation with antioxidant benefits across all skin types.


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References