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3-ETHYL-2-HYDROXY-4-METHYLCYCLOPENT-2-EN-1-ONE.

Optional CAS 42348-12-9 / PERFUMING

A cyclic alpha-diketone fragrance compound that delivers distinctive sweet maple and caramellic olfactory notes to cosmetic formulations. Beyond fragrance masking, this alicyclic ketone may modulate TRPM8 receptors to provide subtle sensory effects on skin.

perfuming sensory modifier

Science

Functions primarily as an olfactory masking agent while potentially interacting with TRPM8 receptors (transient receptor potential melastatin member 8) to create cooling or warming sensations on skin and mucous membranes.


Research

Medium confidence
Effective range 0.1–2.5%
Optimal

0.1%


Transparency

Not commonly dusted

Not typically used for ingredient dusting as it serves a specific fragrance function with noticeable sensory properties


The Formula

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Demonstrates high stability in alcoholic solutions and standard cosmetic bases. Water solubility limited to 1.1 g/L while showing excellent solubility in alcohol and organic oils (logP 0.6-1.1). Heat-sensitive above 260°C.

Conflicts

  • Nitrosating agents
  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
2.5%
Sensitization risk Low

Listed in EU Inventory of Cosmetic Ingredients under general safety requirements. Oral NOEL established at 200-400 mg/kg bw/day with no systemic toxicity, carcinogenicity, or developmental effects observed in long-term studies.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient that serves its specific olfactory purpose effectively, though not essential for skincare benefits.


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