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3-ETHYL-2,4-DIOXASPIRO(5.5)UNDEC-8-ENE.

Optional CAS 64165-57-7 / PERFUMING

A synthetic fragrance molecule with a cyclic acetal structure that delivers fresh, green, and floral notes to cosmetic formulations. Primarily functions as an olfactory enhancer and malodor masking agent rather than providing direct skin benefits.

perfuming masking

Science

Interacts with olfactory receptors through its unique chemical structure to provide a clean, rhubarb-like scent profile while masking unwanted odors in personal care products


Research

Medium confidence
Effective range 0.1–0.5%
Optimal

0.3%

Key findings

  1. 01 IFRA/RIFM safety assessment demonstrating effective fragrance performance at 0.1-0.5% in finished products
  2. 02 Human patch testing at 100% concentration showed mild irritation potential, confirming need for appropriate dilution

Transparency

Not commonly dusted

As a fragrance ingredient, dusting is not a relevant concern for this component


The Formula

Solubility
Oil
Optimal pH 6.5 – 13
0 7 14

Stability

Exhibits excellent stability in alkaline conditions but undergoes hydrolysis in highly acidic environments below pH 4.0 due to its acetal bond structure

Synergies

  • Antimicrobial agents in deodorant formulations

Conflicts

  • Nitrosating agents
  • Strongly acidic formulation components

Safety

CIR Status
Not reviewed
Max tested
6%
Sensitization risk Low

RIFM-evaluated with IFRA 49th Amendment allowing up to 6% in fragrance concentrates, though finished cosmetics typically use <0.5% to minimize sensitization potential


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A well-tolerated fragrance ingredient that serves its olfactory purpose effectively but offers no skincare benefits beyond scent enhancement.


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