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3-AMINO-2,6-DIMETHYLPHENOL.

Avoid CAS 6994-64-5 / HAIR DYEING

A specialized chemical compound primarily designed for oxidative hair coloring systems, functioning as a coupler that reacts with developers to create permanent color pigments. While extensively studied for hair applications, its use in skincare remains limited and largely unexplored.

hair dyeing

Science

Functions through oxidative coupling reactions where it combines with primary intermediates and oxidizing agents to form larger, stable chromophore molecules that provide lasting color effects in hair shaft structures.


Research

Medium confidence
Effective range 1–2%
Optimal

2%

Key findings

  1. 01 Safety evaluation confirmed effectiveness as hair dye coupler but identified potential sensitization concerns
  2. 02 Demonstrated excellent chemical stability with over 99% recovery in aqueous systems over one week

Transparency

Not commonly dusted

Not applicable for skincare formulations as this ingredient is specifically regulated for hair coloring applications only


The Formula

Solubility
Both
Optimal pH 7 – 9.5
0 7 14

Stability

Exhibits exceptional stability exceeding 99% in water-based solutions at neutral pH. Maintains integrity in alkaline conditions typical of hair treatment formulations.

Conflicts

  • Strong oxidizing agents
  • Strong acids

Safety

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Moderate

Regulated under EU Annex III/308 and ASEAN guidelines specifically for hair coloring. European safety authorities acknowledge sensitization potential cannot be ruled out.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Avoid

Not recommended for skincare applications due to regulatory restrictions, sensitization concerns, and lack of established dermatological benefits.


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